| OPPEREINDBAAS |
| The user formerly known as EINDBAAS |
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 Posted 21-04-2024 17:55 by OPPEREINDBAAS |
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Je verwacht het niet.
https://www.cureus.com/articles/196275-increased-age-adjusted-cancer-mortality-after-the-third-mrna-lipid-nanoparticle-vaccine-dose-during-the-covid-19-pandemic-in-japan#!/
quote:
Cancer development by SARS-CoV-2 mRNA vaccine
In our study, the AMRs of ovarian cancer, leukemia, prostate, lip/oral/pharyngeal, pancreatic, and breast cancers increased significantly beyond the predicted rates, especially in 2022. All of these cancers are known as estrogen and estrogen receptor alpha (ERα)-sensitive cancers [78-83]. Recent research by Solis et al. on the binding ability of S-protein of SARS-CoV-2 against over 9,000 human proteins has shown that S-protein specifically binds to ERα and upregulates the transcriptional activity of ERα. The addition of estradiol (E2) to human breast cancer cells causes proliferation of the cancer cells, whereas the addition of raloxifene, a selective ERα modulator, inhibits proliferation. Breast cancer cells grow when S is added instead of E2, and the addition of raloxifene inhibits their growth. Solis et al. also mentioned that the finding of S-ERα cytosolic colocalization may lead to a potentiation of membrane-bound ERα signaling [84]. Membrane-bound ERα has been implicated in many pathways, including the activation of c-Myc, which promotes the cell cycle and impacts cancer development [85].
ERα-mediated transcription may induce endogenous DNA double-strand breaks (DSBs) in ER-sensitive cancers [86]. Studies have shown that transcriptionally activated ERα induces DSBs by topoisomerase II and the recently known R-loop/G-quadruplex structures formation, significantly increasing the need for BRCA1 for their repair in breast cancer cells [87-89]. One study showed nuclear translocation of mRNA and S protein with the nuclear localization signal [90], and an in silico bioinformatic analysis showed interactions between the S2 subunit of S-protein and BRCA1, BRCA2, and P53 [91], possibly resulting in their sequestration and dysfunction. The possible co-occurrence of high BRCA1 demand to repair DNA damage caused by activated transcription via ERα bound with S-protein along with dysfunction of BRCA1 sequestrated by S-protein raises concerns about increased cancer risk in ERα-sensitive cells in mRNA-LNP SARS-CoV-2 vaccine recipients.
As mentioned above, there is also great concern about the risk of dysfunction in the crucial cancer suppressor genes, brca2 and P53, as well as BRCA1, through mechanisms involving downregulation of IRF9 through interference by specific miRNA in exosomes [26] and the possible sequestration by the S2 subunit of S-protein in the vaccine [91]. Impaired BRCA1 activity is associated with higher risk of breast, uterine, and ovarian cancer in women and prostate cancer in men, as well as moderately higher risk of pancreatic cancer in both men and women [92]. BRCA2-associated cancers include breast and ovarian cancer in women, prostate and breast cancer in men, and acute myeloid leukemia in children [26]. These findings are highly consistent with our results.
Additional factors that may contribute to the development of cancer are being investigated. Since endogenous ROS causes oxidative DNA damage [93], excessive oxidative stress resulting from the downregulation of ACE2 by S-protein [57] may contribute to cancer development. One study showed that the downregulation of the Mas receptor promotes the metastasis of epithelial ovarian cancer [94]. ACE2 receptor, bound by S-protein after mRNA-LNP vaccination, may directly cause downregulation and subsequent dysfunction of the Mas receptor, possibly leading to an increased risk of metastasis in vaccinated women with ovarian cancer. The observation that injected LNPs accumulate particularly in the ovaries and bone marrow [38] could better explain our findings of excess mortalities from ovarian cancer and leukemia in 2022. According to an analysis of scientific literature about sex hormone receptors in head and neck squamous cell carcinoma (HNSCC), ERα plays various roles in the biopathology of HNSCC, particularly oropharyngeal cancer. These include promoting DNA hypermutation, facilitating HPV integration, and cooperating with epithelial growth factor receptor (EGFR) [82]. This may explain the increased mortality of lip/oral/pharyngeal cancer in our study.
A recent study showed that SARS-CoV-2 RNA could be reverse-transcribed to DNA and integrated into the human cell genome in vitro [95]. Another study reported that transfected mRNA in the human cells exposed to BNT162b2 leads to unsilencing of the endogenous retrotransposon long interspersed element-1 (LINE-1) and reverse transcription of vaccine mRNA sequences to DNA in the nucleus [96]. Accumulation of vaccine mRNA and reverse-transcribed DNA molecules in the cytoplasm could be expected to induce chronic autoinflammation, autoimmunity, DNA damage, and cancer risk in susceptible individuals [97].
Dwazen die menen wijs te zijn, zijn de ergste dwazen.
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